探究肝功能衰竭并发曲霉菌感染者的临床特征及相关性分析。

随机选取2013年2月至2015年5月于本院进行治疗的肝功能衰竭并发曲霉菌感染者300例，回顾性分析患者的临床资料。

肝功能衰竭患者主要病因为病毒性肝炎，其中最为常见的是HBV感染。在185例确定感染部位的患者中，20%患者存在多部位感染，最常见的感染部位为腹腔，肺部次之。部分患者联合应用多种抗菌药物。患者感染的曲霉菌主要为烟曲霉，占50%以上，其次是黄曲霉和黑曲霉。通过双变量相关分析知Spearman相关系数为0.537（P < 0.01），即基础疾病转归与抗曲霉菌治疗效果呈正相关。

对于肝功能衰竭患者，应在重视基础疾病治疗的基础上，合理选用抗真菌药物并维持适当的疗程。

To investigate the clinical features of patients with liver failure complicated with aspergillus infection and the correlationship analysis.

Total of 300 patients with liver failure complicated with aspergillus infection were randomly selected from February 2013 to May 2015 in our hospital, while the clinical data of patients were analyzed, retrospectively.

The main cause of disease in patients with liver failure was viral hepatitis, HBV infection was the most common cause. Among the 185 patients, 20% patients were with the existence of few parts infection, the most common infection part was the abdominal cavity, followed by the lung. Some patients use a variety of antibiotics. Aspergillus fumigatus was the common Aspergillus, which accounted for more than 50%, followed by Aspergillusflavus and Aspergillus Niger. The correlation coefficient of bivariate analysis was 0.537 (P < 0.01), and the prognosis of basic disease was positively correlated with the effect of anti-Aspergillus.

Patients with liver failure should be attached importance to the treatment of basic diseases, rationally given antifungal drugs and maintain appropriate treatment.