回顾性分析布鲁菌病患者的的临床特征，为临床及时诊治提供理论依据。

收集首都医科大学附属北京地坛医院2008年10月至2016年3月收治的312例布鲁菌病住院患者的临床资料，包括一般临床资料、流行病学、临床表现、实验室指标检查等，进行回顾性分析并总结患者的临床特点。

312例布鲁菌病患者中，急性期患者246例（78.8%），慢性期患者66例（21.2%），有明确流行病学接触史者284例（92.0%）。253例（81.1%）患者表现典型，主要有发热、腰腿痛、关节痛、大汗和乏力；不典型表现病例59例（18.9%），包括消化道症状、呼吸道症状、神经系统症状、运动系统症状或者以颜面部水肿、消瘦起病。急性期发病1个月以内就诊者231例（93.9%），就诊至确诊间隔时间1个月以上者96例（39%）。慢性期主要包括延误诊断和治疗不规范。治愈患者治疗后C-反应蛋白、红细胞沉降率较治疗前显著下降，差异均具有统计学意义（χ² = 79.370、P < 0.001，χ² = 45.784、P < 0.001）。

布鲁菌病临床表现形式多样，典型病例占大多数，但延误诊断比例较高，临床医师应加强对本病的认识与警惕，及时诊断并规范治疗以减少并发症和慢性化的发生。

To investigate the clinical characteristic of brucellosis, and to provide reference for diagnosis and treatment of brucellosis.

The clinical data of 312 patients with brucellosis hospitalized in Beijing Ditan Hospital, Capital Medical University during October 2008 to March 2016 were collected, the clinical characteristics and outcomes including the general condition, epidemiology, clinical manifestation and laboratory examination were analyzed, retrospectively.

Total of 312 cases of brucellosis were enrolled, the acute phase cases and chronic phase cases were 78.8% (246 cases) and 21.2% (66 cases), respectively and 284 cases (92.0%) of them had an epidemic history. There were 253 patients who (81.1%) showed a typical clinical symptoms including fever, low back pain, joint pain, sweating and fatigue and the rest 59 cases (18.9%) had atypical symtoms involving gastrointestinal system, respiratory system, neurological system, motor system and even beginning with facial swelling or weight loss. There were 231 cases (93.9%) in the acute phase going to hospital when infected with brucellosis for less than a month, however, 96 cases (39%) were not diagnosed timely in a month. The chronic phase cases mainly resulted in delayed diagnosis and non-standard treatment. The levels of C-reactive protein and the rates of erythrocyte sedimentation after treatment were significantly lower than those before treatment, with significant differences (χ² = 79.370, P < 0.001; χ² = 45.784, P < 0.001).

The clinical manifestations of brucellosis were diverse, typical cases accounts for the majority, but the proportion of delayed diagnosis cases was still high, clinicians should strengthen the awareness and vigilance of the disease, timely diagnosis and standard treatment could reduce complications and chronic cases.