分析本地区女性HPV感染现状，为预防HPV感染和宫颈癌提供理论依据。

采用PCR-膜杂交法对本院门诊收治的778例女性患者进行21种HPV基因分型检测。

共检测出289例HPV感染者，HPV感染率为37.15%，其中高危型感染占74.74%，低危型感染占17.65%，高、低危型混合感染占7.61%。高危型感染率最高的前5型别为HPV16（9.13%）、HPV58（7.46%）、HPV52（5.53%）、HPV33（3.60%）和HPV31（2.31%），低危型以HPV6（3.99%）和HPV11（2.31%）为主。HPV高危型感染率（30.59%）显著高于HPV低危型感染率（9.38%），差异具有统计学意义（χ² = 707.152、P < 0.001）。高危型多重感染率（21.34%）显著高于低危型多重感染率（2.00%），差异具有统计学意义（χ² = 457.201、P < 0.001）。在HPV阳性者中单纯感染228例（78.89%），多重感染61例（21.11%）。各年龄段HPV感染率差异无统计学意义（χ² = 4.096、P = 0.393），各年龄段感染类型均以高危型为主。

高危型感染以HPV16、HPV52和HPV58为最常见型别，低危型感染以HPV6最常见。感染类型以单纯感染和高危型感染为主。多重感染以高危型和高、低混合型感染常见。该地区女性HPV感染情况与年龄无关。

To investigate the infection of human papillomavirus (HPV) in local female patients and to provide valuable data for preventing HPV infection and cervical cancer occurrence.

Total of 21 types of HPV genotype were examined by PCR-Membrane hybridization technique in 778 women belonging to the outpatients of Shiyan Renmin Hospital.

Among those 778 tested women there are 289 HPV positive patients and the infection rate was 37.15%. As for the proportion of HPV infection, 74.74% were high-risk HPV infections and 17.65% were low-risk HPV infections, while the other 7.61% were the combination of high-risk and low-risk HPV infections. The top five genotypes of high-risk HPV infection are HPV16 (9.126%), HPV58 (7.455%), HPV52 (5.527%), HPV33 (3.599%) and HPV31 (2.314%). And the main genotypes of low-risk HPV infection were HPV6 (3.985%) and HPV11 (2.314%). In this region, the infection rate of high-risk HPV (30.59%) was significantly higher than that of low-risk HPV (9.38%) (χ² = 707.152, P < 0.001). And the infection rate of high-risk HPV multiple infection (21.34%) was also significantly higher compered with the infection rate of low-risk HPV multiple infection (2.00%) (χ² = 457.201, P < 0.001). While the infection rates for the monotonous genotype of HPV infection and the multiple genotypes of HPV infection were 78.89% and 21.11%, respectively. And there is no significant difference between the infection rates of HPV in five age groups (χ² = 4.096, P = 0.393). Totally high-risk HPV infection takes the majority of HVP infection in all groups.

HPV16, HPV52 and HPV58 were the most common genotypes of high-risk HPV infection, and HPV6 was the principal genotype of low-risk HPV infection. The main types of HPV infection was high-risk HPV infection and monotonous genotype of HPV infection. Multiple genotypes of HPV infections was mainly caused by high-risk HPV infection and high-risk and low-risk mixed HPV infections. HPV infection in women in this region is independent of age.