探讨孕期妇女感染宫颈人乳头瘤病毒（HPV）的基因型分布。

选取2013年1月至2014年12月期间本院产科门诊就诊的400例孕期妇女作为研究对象，按不同孕期将其分为孕早期（14周以下）153例、孕中期（14～28周）146例和孕晚期（28周以上）101例；按年龄分为3组，≤ 24岁组152例，25～28岁组146例，≥ 29岁组102例。对孕期妇女宫颈脱落细胞进行HPV DNA分型检测，分析不同孕期和不同年龄妇女宫颈人乳头瘤病毒感染率和23种基因型的分布。

400例孕期妇女中人乳头瘤病毒阳性检出67例，总感染率为16.63%，孕早期、中期和晚期的感染率分别为18.51%、13.76%和19.54%，不同孕期妇女HPV感染率差异无统计学意义（χ² = 2.187、P = 0.167）。孕期妇女宫颈最常见的HPV感染亚型及其感染率分别为HPV16（21例，5.25%）、HPV6（13例，3.25%）、HPV11（11例，2.75%）、HPV18（10例，2.50%）和HPV52（14例，3.50%）。孕期妇女年龄≤ 24岁时有较高感染率（99例，24.75%），年龄25～28岁孕妇感染率为12.25%（49例，12.25%），年龄≥ 29岁孕妇感染率为15.25%（61例，15.25%），差异具有统计学意义（χ² = 7.884、P = 0.031）。

孕期妇女宫颈人乳头瘤病毒感染率较高，且24岁以下孕期妇女感染率尤为突出。最常见基因型为HPV16，其次为HPV52、HPV6、HPV11和HPV18。

To investigate the genotype distribution of pregnant women with cervical human papillomavirus (HPV) infection.

Total of 400 cases of pregnant women were selected from January 2013 to December 2014 in maternity clinic of our hospital, and were divided into three different groups: the first trimester (≤ 14 weeks) with 153 cases, the second trimester (14-28 weeks) with 146 cases and the third trimester (> 28 weeks) with 101 cases. According to the age, the 400 cases were divided into 3 groups, ≥ 24 years old group with 152 cases, 25-28 years old group with 146 cases and ≥ 29 years old group with 102 cases. HPV DNA typing was detected, while the infection rate and the distribution of genotypes of HPV infection rate and 23 genotypes of cervical HPV in pregnant women during pregnancy were analyzed, respectively.

There were 67 cases with HPV positive among the 400 pregnant women, the total infection rate was 16.63%, the infection rate in early, middle and late stage were 18.51%, 13.76% and 19.54%, respectively. The infection rate of case with different pregnancy stages were significantly different (χ² = 2.187, P = 0.167). The most common subtype of cervical HPV infection were HPV16 (21 cases, 5.25%), HPV6 (13 cases, 3.25%), HPV11 (11 cases, 2.75%), HPV18 (10 cases, 2.50%) and HPV52 (14 cases, 3.50%). Pregnant women ≥ 24 years old had a higher infection rate (99 cases, 24.75%), while the infection rate was 12.25% (49 cases, 12.25%) in cases of 25-28 years old group, in pregnant women ≥ 29 years old with the infection rate of 15.25% (61 cases, 15.25%), with significant differences (χ² = 7.884, P = 0.031).

Cervical HPV infection in pregnant women was higher, and the infection rate of pregnant women of 24 years old was particularly prominent. The most common subtype was HPV16, followed by HPV52, HPV6, HPV11 and HPV18.