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中华实验和临床感染病杂志(电子版) ›› 2016, Vol. 10 ›› Issue (06) : 703 -707. doi: 10.3877/cma.j.issn.1674-1358.2016.06.011

临床论著

降钙素原和超敏C-反应蛋白检测在小儿支气管肺炎中的应用
余东阳1,(), 李真2, 余卉1, 刘少平1, 邵亚苹1   
  1. 1. 431700 天门市,天门市第一人民医院检验科
    2. 431700 天门市,天门市第一人民医院儿科
  • 收稿日期:2015-10-27 出版日期:2016-12-15
  • 通信作者: 余东阳

Application of procalcitonin and hsCRP detection in children with bronchial pneumonia

Dongyang Yu1,(), Zhen Li2, Hui Yu1, Shaoping Liu1, Yaping Shao1   

  1. 1. Department of Laboratory, The First People’s Hospital of Tianmen, Tianmen 431700, China
    2. Deptartment of Pediatrics, The First People’s Hospital of Tianmen, Tianmen 431700, China
  • Received:2015-10-27 Published:2016-12-15
  • Corresponding author: Dongyang Yu
引用本文:

余东阳, 李真, 余卉, 刘少平, 邵亚苹. 降钙素原和超敏C-反应蛋白检测在小儿支气管肺炎中的应用[J/OL]. 中华实验和临床感染病杂志(电子版), 2016, 10(06): 703-707.

Dongyang Yu, Zhen Li, Hui Yu, Shaoping Liu, Yaping Shao. Application of procalcitonin and hsCRP detection in children with bronchial pneumonia[J/OL]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2016, 10(06): 703-707.

目的

探讨血清降钙素原(PCT)和超敏C-反应蛋白(hsCRP)的检测在小儿支气管肺炎中的应用价值。

方法

收集80例感染者样本(一般感染组和严重感染组患者各40例),另选择40例健康体检中心正常儿童为对照组。分别检测样本中PCT、hsCRP浓度、白细胞数(WBC)和Sepsis评分值,比较两个感染组患者与对照组血清PCT、hsCRP、WBC计数和Sepsis评分的差异,分别比较两个感染组患者PCT、hsCRP、WBC计数和Sepsis评分治疗前后的差异。

结果

治疗前,一般感染组和严重感染组患者分别与对照组相比,PCT、hsCRP、WBC计数和Sepsis评分差异均具有统计学意义(P均< 0.05)。治疗后,感染组患者的各项指标与治疗前差异均具有统计学意义(P均< 0.05)。治疗后,严重感染组与一般感染组患者各指标相比,PCT、hsCRP和WBC计数水平差异具有统计学意义(P均< 0.05);但两组Sepsis评分差异无统计学意义(t = 0.821、P = 0.241)。

结论

血清PCT水平、hsCRP水平与小儿支气管肺炎严重程度呈正相关,PCT与hsCRP检测对小儿支气管肺炎的诊断与治疗具有重要的指导意义。

Objective

To investigate the application value of serum procalcitonin and high sensitivity C-reactive protein (hsCRP) in children with bronchial pneumonia.

Methods

Total of 80 specimens from 80 cases with infection (40 cases with general infection and 40 cases with severe infection) were collected, while 40 cases from physical examination center were collected as control group. The levels of PCT, hsCRP and WBC counts were detected, and the score of sepsis were calculated, respectively. The levels of PCT, hsCRP, WBC and sepsis score were compared among two infection groups and the control group, respetively, and the levels of PCT, hsCRP, WBC and sepsis score of two infection groups were compared before and after treatment, respectively.

Results

Before treatment, the levels of PCT, hsCRP, WBC and sepsis score of patients in infection group were significantly different compared with those of control group (all P < 0.05). After treatment, all indexes of patients in infection group had significant differences compared with the indexes before treatment (all P < 0.05). The levels of PCT, hsCRP, WBC counts of patients in severe infection had significant differences compared with those in general infection group after treatment (all P < 0.05), but sepsis score had no significant differences between the two groups (t = 0.821, P = 0.241).

Conclusions

Serum PCT and hsCRP were positively correlated with infantile bronchial pneumonia severity, which could guide the treatment and curative effect of bronchopneumonia.

表1 各组研究对象治疗前后血清PCT、hsCRP、WBC及Sepsis值(±s
表2 各组患者血清PCT、hsCRP、WBC计数及Sepsis评分组内与组间差异
1
Don M, Valent F, Korppi M, et al. Efficacy of serum procalcitonin in evaluating severity of community-acquired pneumonia in childhood[J]. Scand J Infect Dis,2007,39(2):129-137.
2
王世瑜,谭广群,穆红, 等. 血清降钙素原定量检测在呼吸道感染中的应用[J]. 广东医学,2013,34(18):2826-2828.
3
曾宪威. 降钙素原和C-反应蛋白水平及白细胞计数[J/CD]. 中华实验和临床感染病杂志:电子版,2011,10(1):69-72.
4
孙东明,董巧丽,杨小巍, 等. 降钙素原及超敏C-反应蛋白在新生儿败血症早期诊断中的临床价值研究[J]. 现代预防医学,2012,39(9):2169-2170.
5
Bustos BR, Araneda CH. Procalcitonin for the diagnosis of late onset sepsis in newborns of very low birth weight[J]. Rev Chilena Infectol,2012,29(5):511-6.
6
张敏,陈浩,曹明. 降钙素原检测在感染性疾病诊断中的价值[J/CD]. 中华实验和临床感染病杂志:电子版,2015,9(5):678-680.
7
Dellinger RP, Levy MM, Carlet JM, et al. Survjving sepsis campaign: intemational guidelines for management of severe sepsis and septic shock: 2008[J]. Crit Care Med,2008,36(1),296-327.
8
李未今. PCT, Fb和CRP检测在感染性疾病诊断中的应用[J]. 放射免疫学杂志,2013,26(6):800-801.
9
朱名超,韩利蓉,孙莉, 等. 降钙素原与超敏C-反应蛋白在感染性和非感染性疾病中的应用价值评价[J/CD]. 中华实验和临床感染病杂志:电子版,2014,8(5):658-660.
10
Gong HC, Yang ND, Liu Z, et al. Regulatory effects of insulin-like growth factor-1 on the expression of sensory neuropeptide mRNAs in cultured dorsal root ganglion neurons with excitotoxicity induced by glutamate[J]. Neurosci Bull,2010,26(2):126-32.
11
施立新,刘云庆,毛宜虎, 等. 血浆降钙素原在呼吸道感染中的应用[J]. 国际检验医学杂志,2013,36(24):3363-3364.
12
胡树家,张婷,黎达均, 等. 血清降钙素原检测指导下呼吸道感染患儿抗生素合理应用的探讨[J]. 临床和实验医学杂志,2013,12(11):830-834.
13
降钙素原急诊临床应用专家共识组. 降钙素原(PCT)急诊临床应用的专家共识[J]. 中华急诊医学杂志,2012,21(9):944-951.
14
任芳萍,刘玲莉,吴昌归, 等. 降钙素原在感染性疾病中的诊断及预测价值[J/CD]. 中华实验和临床感染病杂志:电子版,2013,7(2):306-309.
15
司志燕,段君君,宋文奇, 等. 血清降钙素原与C-反应蛋白的医院感染诊断价值[J]. 中国感染控制杂志,2014,13(3):158-160.
16
蒋伟,李少增,周峥. 定量检测降钙素原在患者感染诊断及其预后判断中的临床价值[J]. 中国感染控制杂志,2012,11(3):189-191.
17
卢忠芳. C-反应蛋白在急性呼吸道感染及治疗中的应用[J]. 检验医学与临床,2013,10(1):87-88.
18
Sllamniku-Dalipi Z, Mehmeti H, Dragidella F, et al. Elevated levels of inflammatory cytokines and high-sensitivity C-reactive protein in periodontitis patients in Kosovo: a pilot study[J]. OJST,2013,3(1):32-38.
19
唐小宇,颜怀安. C-反应蛋白和血清降钙素原对危重患者感染的监测价值研究[J/CD]. 中华实验和临床感染病杂志:电子版,2014,8(5):658-660.
20
陈平,刘健,李海珠, 等. PCT与hs-CRP在新生儿炎症性疾病中的比较[J]. 实验与检验医学,2012,30(6):601-603.
21
Briel M, Schuetz P, Mueller B, et al. Procalcitonin-guided antibiotic use vs a standard approach for acute respiratory tract infections in primary care[J]. Arch Intern Med,2008,168(18):2000-2007.
22
蔓春,马恒颢. 血清降钙素原水平监测对指导新生儿细菌感染抗菌疗程的意义[J]. 国际检验医学杂志,2012,33(t1):1299-1300.
23
Limper M, de Kruif MD, Duits AJ, et al. The diagnostic role of procalcitoninand other biomarkers in discriminating infectious from non-infectious fever[J]. J Infect,2010,60(6):409-416.
24
孔繁荣,由晓颜,吴天歌. 血浆内毒素与C-反应蛋白及血清降钙素原筛查细菌感染性疾病的价值[J]. 中华实用诊断与治疗杂志,2014,28(5):500-501.
25
袁高品,杨健. 降钙素原评估儿童创伤严重程度和创伤后脓毒症的研究[J]. 四川大学学报医学版,2012,43(5):706-710.
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