探讨对妊娠期梅毒患者采取临床干预对妊娠结局的影响，为妊娠期梅毒孕妇的临床治疗提供参考。

选取2010年1月至2015年1月本院收治的90例妊娠期梅毒孕妇，根据其临床干预的时间，首次筛查时快速血浆反应素环状卡片试验（RPR）的滴度及孕期梅毒治疗情况进行分组，并对其妊娠结局进行比较。

妊娠期梅毒患者孕20周前（65例）和孕20周后（15例）进行临床干预，不良妊娠结局（流产、早产、死胎死产、先天梅毒等）发生率分别是3.08%和20%，差异具有统计学意义（χ² = 7. 521、P = 0.012）。90例梅毒孕妇根据孕期治疗情况，分为规范治疗组（60例）、不规范治疗组（20例）和未治疗组（10例），不良妊娠结局发生率分别为1.67%（1/60）、20%（4/20）和60%（6/10），三组差异具有统计学意义（χ² = 13.863、P = 0.001）；80例采取临床干预的妊娠期梅毒孕妇根据首次筛查时RPR滴度分为≤ 1︰4（66例）和≥ 1︰8（14例）两组，RPR滴度≤ 1︰4组不良妊娠结局发生率为1.52%（1/66），显著低于RPR滴度≥ 1︰8组的孕妇不良结局发生率28.57%（4/14），差异具有统计学意义（χ² = 8.102、P = 0.011）。

对妊娠期梅毒患者的早期诊断、规范性治疗，可显著改善妊娠结局，提高出生人口质量。

To investigate the impact of clinical interventions for the pregnant patients with syphilis on pregnancy, and to provide guidance for clinical treatment of syphilis infection in the pregnant women.

Total of 90 cases of pregnant women infected with syphilis in our hospital from January 2010 to January 2015 were enroelled, according to clinical intervention time, the first screening of RPR titers and treatment of syphilis during pregnancy, they were divided into groups, while the pregnancy outcomes were analyzed.

The incidence of adverse pregnancy outcomes (including miscarriage, prematurity, stillbirth and congenial syphilis) before 20 weeks and after 20 weeks of pregnancy were 3.08% and 20.00%, with significant differences (χ² = 7. 521, P = 0.012). The incidence of adverse pregnancy outcomes were 1.67% (1/60), 20% (4/20) and 60% (6/10) in the standard treatment group (60 cases), nonstandard treatment group (20 cases) and non-treated group (10 cases), with significant differences (χ² = 13.863, P = 0.001). Among the 80 cases, there were 66 cases with titer ≤ 1︰4, 14 cases with titer≥ 1︰8. The incidence of adverse pregnancy outcomes was 1.52% (1/66) in ≤ 1︰4 group, and significantly lower than that of ≥ 1︰8 group which was 28.57% (4/14), with significant differences (χ² = 8.102, P = 0.011).

Early diagnosis and standard treatment of syphilis in pregnant women could improve the pregnancy outcome and the quality of birth population.