切换至 "中华医学电子期刊资源库"

中华实验和临床感染病杂志(电子版) ›› 2016, Vol. 10 ›› Issue (03) : 319 -322. doi: 10.3877/cma.j.issn.1674-1358.2016.03.014

临床论著

上消化道症状与幽门螺杆菌感染及胃癌前疾病的相关性
谢琼,1, 卢月月1, 易宏锋,1   
  1. 1. 434000 荆州市,湖北省荆州市第一人民医院消化内科
  • 收稿日期:2015-07-27 出版日期:2016-06-15
  • 通信作者: 谢琼, 易宏锋

Correlation of upper gastrointestinal symptoms between Helicobacter pylori infection and gastric precancerous disease

Qiong Xie,1, Yueyue Lu1, Hongfeng Yi,1   

  1. 1. Department of Gastroenterology, The First People’s Hospital of Jingzhou, Hubei 434000, China
  • Received:2015-07-27 Published:2016-06-15
  • Corresponding author: Qiong Xie, Hongfeng Yi
引用本文:

谢琼, 卢月月, 易宏锋. 上消化道症状与幽门螺杆菌感染及胃癌前疾病的相关性[J/OL]. 中华实验和临床感染病杂志(电子版), 2016, 10(03): 319-322.

Qiong Xie, Yueyue Lu, Hongfeng Yi. Correlation of upper gastrointestinal symptoms between Helicobacter pylori infection and gastric precancerous disease[J/OL]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2016, 10(03): 319-322.

目的

探讨上消化道症状与幽门螺杆菌(HP)感染及胃黏膜癌前病变的相关性。

方法

选择2013年1月至2014年10月于本院门诊初诊为慢性胃炎的患者,其中上消化道症状阳性组的患者360例,上消化道症状阴性组患者360例,所有患者均通过碳14呼气试验进行HP检测及胃镜下活检,分别比较有无上消化道症状与患者HP阳性检出率的相关性;以及有无上消化道症状与胃镜活检诊断为胃癌前疾病的相关性。

结果

上消化道症状阳性组患者HP检出率高于上消化道症状阴性组(χ2 = 353.892、P = 0.000);上消化道症状阳性组患者慢性胃炎伴不典型增生发病率显著高于上消化道症状阴性组,差异具有统计学意义(χ2 =12.328、P = 0.000)。

结论

上消化道症状与HP感染具有相关性,上消化道症状与慢性胃炎伴不典型增生具有相关性。

Objective

To explore the correlation of gastrointestinal symptoms, Helicobacter pylori (HP) infection and gastric precancerous diseases.

Methods

Patients diagnosed as chronic gastritis were selected from January 2013 to October 2014. Then the patients were divided into upper gastrointestinal symptoms of positive group (360 cases) and negative group (360 cases). All patients were tested by 14C breath test and diagnosised with biopsy in endoscopy. The relationship between the upper gastrointestinal symptoms in patients with HP positive rate and the upper gastrointestinal symptoms with endoscopy biopsy diagnosis of precancerous disease were compared, respectively.

Results

The HP detection rate of upper gastrointestinal symptoms positive group was significantly higher than that of negative group (χ2 = 353.892, P = 0.000). The incidence of chronic gastritis with symptoms of upper gastrointestinal dysplasia positive group was significantly higher than that of negative group (χ2 = 12.328, P = 0.000).

Conclusions

Upper gastrointestinal symptoms was correlated with HP infection, and there were relevantion between upper gastrointestinal symptoms and chronic gastritis.

表2 上消化道症状与胃癌前病变检出率的比较[例(%)]
1
Adamczyk M, PeczekŁ, Rudnicki C, et al. The clinical significance of gastropanel in diagnostics of Helicobacter pylori eradication efficiency in patients with dyspepsia with correlation of family history of gastric cancer[J]. Pol Merkur Lekarski,2013,35(207):141-147.
2
刘文忠,萧树东. 幽门螺杆菌新国际共识解读[J]. 胃肠病学,2012,17(1):1-4.
3
Suzuki H, Nishizawa T, Hibi T. Can Helicobacter pylori-associated dyspepsia be categorized as functional dyspepsia?[J]. J Gastroenterol Hepatol,2011,26(3):42-45.
4
Jafarzadeh A, Nemati M, Rezayati MT, et al. Higher circulating levels of anti-phosphatidylserine antibody in peptic ulcer patients infected with CagA-positive strains of Helicobacter pylori[J]. Clin Lab,2013,59(9-10):977-984.
5
Liu J, He C, Chen M, et al. Association of presence/absence and on/off patterns of Helicobacter pylori oipA gene with peptic ulcer disease and gastric cancer risks:a meta-analysis[J]. BMC Infect Dis,2013,13:555.
6
黄叶妮,刘丽. 幽门螺杆菌感染的治疗进展[J]. 现代生物医学进展,2012,12(17):3398-3399.
7
成积儒,蔡永林,黄德旺, 等. 336例上消化道疾病患者的幽门螺杆菌抗体谱检测结果分析[J]. 广西医学,2009,31(6):807-808.
8
Futagami S, Shimpuku M, Yin Y, et al. Pathophysiology of functional dyspepsia[J]. J Nihon Med Sch,2011,78(5):280-285.
9
Lansdorp-Vogelaar I, Sharp L. Cost-effectiveness of screening and treating Helicobacter pylori for gastric cancer prevention[J]. Best Pract Res Clin Gastroenterol,2013,27(6):933-947.
10
Miwa H, Watari J, Fukui H, et al. Current understanding of pathogenesis of functional dyspepsia[J]. J Gastroenterol Hepatol,2011,26(3):53-60.
11
Suzuki H, Matsuzaki J, Hibi T. What is the difference between Helicobacter pylori-associated dyspepsia and functional dyspepsia?[J]. J Neurogastroenterol Motil,2011,17(2):124-130.
12
Saito Y, Suzuki H, Tsugawa H, et al. Dysfunctional gastric emptying with down-regulation of muscle-specific microRNAs in Helicobacter pylori-infected mice[J]. Gastroenterology,2011,140(1):189-198.
13
Takeuchi K, Ohishi M, Ota S, et al. Metabolic profiling to identify potential serum biomarkers for gastric ulceration induced by nonsteroid anti-inflammatory drugs[J]. J Proteome Res,2013,12(3):1399-1407.
14
于中麟. 慢性胃炎的内镜分型分级标准及治疗的试行意见[J]. 中华消化内镜杂志,2004,21(2):4-5.
15
Kato M, Ono S, Yoshida T, et al. Significance of H. pylori eradication in treatment and prevention for low-dose aspirin induced gastric ulcer of elderly[J]. NihonRinsho,2010,68(11):2089-2095.
16
Naqano Y, Matsui H, Tamura M, et al. NSAIDs and acidic environment induce gastric mucosal cellular mitochondrial dysfunction[J]. Digestion,2012,85(2):131-135.
17
朱玉群,杨绍徐. 幽门螺旋菌感染与胃癌的相关性研究[J]. 首都医科大学学报,2009,3(17):49-50.
18
Boike JR, Kao R, Meyer D, et al. Does concomitant use of paracetamol potentiate the gastroduodenal mucosal injury associated with aspirin? A prospective, randomised, pilot study[J]. Aliment Pharmacol Ther,2012,36(4):391-397.
19
朱敏,袁昌琼,杨慧英, 等. 胃肠外疾病患者幽门螺旋杆菌感染治疗探析[J]. 河北医学,2013,19(12):1795-1797.
20
Seo PJ, Kim N, Kim JH, et al. Comparison of indomethacin, diclofenac and aspirin-induced gastric damage according to age in rats[J]. Gut Liver,2012,6(2):210-217.
21
Tamural I, Fujita T, Tsumura H, et al. Low-dose aspirin-induced gastroduodenal mucosal injury in Japanese patients with arteriosclerotic disease[J]. Inter Med,2010,49(23):2537-2545.
22
Ryter SW, Cloonan SM, Choi AM. Autophagy: a critical regulator of cellular metabolism and homeostasis[J]. Mol Cells,2013,36(1):7-16.
23
Chen HC, Fong TH, Lee AW, et al. Autophagy is activated in injured neurons and inhibited by methylprednisolone after experimental spinal cord injury[J]. J Spine,2012,37:470-475.
24
He LQ, Lu JH, Yue ZY. Autophagy in ageing and ageing-associated diseases[J]. Acta Pharmacol Sin,2013,34(5):605-611.
25
Naqano Y, Matsui H, Tamura M, et al. NSAIDs and acidic environment induce gastric mucosal cellular mitochondrial dysfunction[J]. Digestion,2012,85(2):131-135.
[1] 王培蕾, 夏罕生, 俞清, 闻捷先, 黄备建. IgG4相关性乳腺炎多模态影像学表现及其治疗转归一例[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(04): 244-247.
[2] 李世杰, 申传安. 烧伤合并吸入性损伤患者呼吸机相关肺炎的研究现状[J/OL]. 中华损伤与修复杂志(电子版), 2024, 19(04): 351-355.
[3] 崔玉峰, 林毅军, 王志民. 幽门螺杆菌分子检测技术研究进展[J/OL]. 中华实验和临床感染病杂志(电子版), 2024, 18(05): 257-262.
[4] 郭伟仪, 林沛玲. 不同抗体型幽门螺杆菌感染与溃疡性结肠炎患者疾病活动及组织学评分的关系[J/OL]. 中华实验和临床感染病杂志(电子版), 2024, 18(04): 237-244.
[5] 陈嘉艺, 陈佳, 张曦, 张琦. 伴有“反晕征”的IgG4 相关性肺疾病一例并文献复习[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(05): 844-846.
[6] 杨柳, 陈佳, 孙雅娟, 陈娇, 谭明超, 龚明福. 抗中性粒细胞胞浆抗体相关性血管炎的胸部CT 及临床特征分析[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(05): 744-749.
[7] 刘春军, 严方方, 王宝锋, 常婷婷, 郭红红, 李志强. 替加环素联合人免疫球蛋白治疗XDRAB致VAP 的疗效分析[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(05): 797-800.
[8] 李多, 郝昭昭, 陈延伟, 南岩东. 血清PTX3表达与非小细胞肺癌骨转移的相关性分析[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(04): 558-562.
[9] 燕红玲, 王岩岩, 陈树斌. PCT、NLR联合LUBS预测ICU CRKP致呼吸机相关肺炎撤机及预后分析[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(04): 617-620.
[10] 王涛, 刘静, 高玉伟, 王兴华, 胡秀红, 崔红蕊, 徐保振, 杨洪娟. 抗生素耐药背景下中医药防治腹膜透析相关性腹膜炎研究进展[J/OL]. 中华肾病研究电子杂志, 2024, 13(06): 340-344.
[11] 刘思含, 张静. 老年人血清铁与C 反应蛋白的比值及25-羟基维生素D3 与肾功能受损的关系研究[J/OL]. 中华肾病研究电子杂志, 2024, 13(05): 268-272.
[12] 杨森, 阙玉梅, 丁莉, 王艺瑾, 侯庆宇. Hcy和AD7c-NTP在阿尔茨海默病诊断中的临床应用[J/OL]. 中华脑科疾病与康复杂志(电子版), 2024, 14(04): 208-212.
[13] 杨卫东, 周威, 向洪涛. 慢性萎缩性胃炎患者幽门螺杆菌感染与炎性细胞因子及病理特征的关系[J/OL]. 中华消化病与影像杂志(电子版), 2024, 14(05): 459-464.
[14] 刘志超, 胡风云, 温春丽. 山西省脑卒中危险因素与地域的相关性分析[J/OL]. 中华脑血管病杂志(电子版), 2024, 18(05): 424-433.
[15] 李璇, 邓岚, 郭微, 邓永梅, 刘杰昕. 标准化皮肤管理流程在防治脑卒中患者失禁相关性皮炎中的应用[J/OL]. 中华脑血管病杂志(电子版), 2024, 18(05): 479-482.
阅读次数
全文
1
HTML PDF
最新录用 在线预览 正式出版 最新录用 在线预览 正式出版
0 0 0 0 0 1

  来源 其他网站
  次数 1
  比例 100%

摘要
27
最新录用 在线预览 正式出版
0 0 27
  来源 本网站 其他网站
  次数 12 15
  比例 44% 56%