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中华实验和临床感染病杂志(电子版) ›› 2021, Vol. 15 ›› Issue (02) : 73 -77. doi: 10.3877/cma.j.issn.1674-1358.2021.02.001

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综述

妊娠期新型冠状病毒肺炎研究进展
梁毓1, 王树玉1,()   
  1. 1. 100026 北京,首都医科大学附属北京妇产医院生殖医学科
  • 收稿日期:2020-07-24 出版日期:2021-04-15
  • 通信作者: 王树玉
  • 基金资助:
    北京市属医院科研培育项目(No. PX2021054)

Advances in pregnant women with coronavirus disease 2019

Yu Liang1, Shuyu Wang1,()   

  1. 1. Human Reproductive Medicine Department, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China
  • Received:2020-07-24 Published:2021-04-15
  • Corresponding author: Shuyu Wang
引用本文:

梁毓, 王树玉. 妊娠期新型冠状病毒肺炎研究进展[J/OL]. 中华实验和临床感染病杂志(电子版), 2021, 15(02): 73-77.

Yu Liang, Shuyu Wang. Advances in pregnant women with coronavirus disease 2019[J/OL]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2021, 15(02): 73-77.

新型冠状病毒肺炎(COVID-19)为新发急性呼吸道传染病,是严重的突发卫生公共事件。孕妇作为一类特殊群体,为新型冠状病毒(SARS-CoV-2)易感人群,因其特殊生理状态,病毒感染时会有与妊娠相关的临床特点,诊断和治疗也更为棘手。此外,妊娠期COVID-19对胎儿的影响亦是目前研究非常关注的问题。妊娠期COVID-19的临床表现与非妊娠患者相似,主要表现为发烧、咳嗽、呼吸困难和淋巴细胞计数减少;大部分COVID-19孕妇预后良好,但随着疫情的蔓延,部分国家和地区逐渐有孕妇因COVID-19而导致临床结局不佳的报道。截至2020年9月,尚未发现SARS-CoV-2通过胎盘垂直传播引起胎儿宫内感染的证据,但与普通人群相比,妊娠期COVID-19子痫前期、早产、胎儿宫内发育受限发生率更高。但现阶段对孕产妇COVID-19的认知仍十分有限,需在临床实践中不断总结经验教训,加强科研攻关,进一步深入了解COVID-19对母胎的影响。本文对妊娠期COVID-19的疾病特点、诊断、治疗及对胎儿、新生儿的影响进行综述。

The novel COVID-19 is a new acute respiratory infectious disease, which is a serious public health emergency. As a special group, pregnant women are susceptible to severe acute respiraory syndrome coronavirus 2 (SARS-CoV-2). Due to their special physiological state, pregnant women with SARS-CoV-2 infection will have pregnancy related clinical characteristics, while the diagnosis and treatment are more difficult. In addition, the impact of pregnant COVID-19 on the fetus is also a matter of great concern. Similar to nonpregnant patients, the predominant features of COVID-19 in pregnant patients are fever, cough, dyspnea and lymphopenia. Most patients have good prognosis, however, with the spread of the epidemic, some countries and regions have reported that pregnant women had poor clinical outcomes due to COVID-19 disease. Up to September 2020, the evidence of intrauterine infection caused by vertical transmission of SARS-CoV-2 through placenta had not been found. However, compared with general population, the rates of incidence of preeclampsia, premature delivery and intrauterine growth restriction of COVID-19 during pregnancy were higher. At present, the understanding of COVID-19 is still very limited. The experience and lessons in clinical practice should be summed up continuely, scientific research should be strengthened to tackle key problems and further understand of the influence of COVID-19 on mother and fetus should be done. This paper presents a review of characteristics, diagnosis, treatment and influence on fetal newborns of COVID-19 during pregnancy.

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