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中华实验和临床感染病杂志(电子版) ›› 2026, Vol. 20 ›› Issue (02) : 93 -97. doi: 10.3877/cma.j.issn.1674-1358.2026.02.004

综述

JC多瘤病毒流行病学及诊疗研究进展
张雨霖, 熊勇()   
  1. 430071 武汉市,武汉大学中南医院感染科、武汉大学艾滋病研究中心
  • 收稿日期:2025-05-30 出版日期:2026-04-15
  • 通信作者: 熊勇
  • 基金资助:
    国家重点研发计划(2023YFC2306603); 武汉大学中南医院学科培育项目(ZNXKPY2021025)

Research progress on the epidemiology, diagnosis and treatment of JC polyomavirus

Yulin Zhang, Yong Xiong()   

  1. Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, AIDS Research Center of Wuhan University, Wuhan 430071, China
  • Received:2025-05-30 Published:2026-04-15
  • Corresponding author: Yong Xiong
引用本文:

张雨霖, 熊勇. JC多瘤病毒流行病学及诊疗研究进展[J/OL]. 中华实验和临床感染病杂志(电子版), 2026, 20(02): 93-97.

Yulin Zhang, Yong Xiong. Research progress on the epidemiology, diagnosis and treatment of JC polyomavirus[J/OL]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2026, 20(02): 93-97.

JC多瘤病毒(JCPyV)是一种广泛分布于人群中的DNA病毒,通常在免疫功能正常的宿主中保持潜伏状态。当宿主免疫功能受损时,JCPyV可重新激活并引发进行性多灶性白质脑病(PML),是一种严重的中枢神经系统脱髓鞘疾病。本文对JCPyV的流行病学特征、分子生物学特性、致病机制及其相关疾病研究进展进行综述,并探讨当前诊断方法、治疗策略以及未来研究方向,为JCPyV感染相关疾病的预防和治疗提供理论参考。

JC polyomavirus (JCPyV) is a widely distributed DNA virus in the human population, typically remaining latent in immunocompetent hosts. When the immune function of the host is compromised, JCPyV can be reactivated and cause progressive multifocal leukoencephalopathy (PML), a severe central nervous system demyelinating disease. This review summarizes the global epidemiological characteristics, molecular biological properties, pathogenesis and related disease research progress of JCPyV, and discusses current diagnostic methods, therapeutic strategies and future research directions, providing theoretical references for the prevention and treatment of JCPyV-associated diseases.

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