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中华实验和临床感染病杂志(电子版) ›› 2025, Vol. 19 ›› Issue (05) : 265 -270. doi: 10.3877/cma.j.issn.1674-1358.2025.05.002

综述

胃微生物菌群与胃癌发生发展的相关性及其作用机制研究进展
范晓彬1, 吕英淑1, 张瑞娟1, 李文星2, 连彦军1,()   
  1. 1 054000 邢台市,邢台市中心医院胃肠外科
    2 030001 太原市,山西医科大学第二医院胃肠外科
  • 收稿日期:2025-03-20 出版日期:2025-10-15
  • 通信作者: 连彦军
  • 基金资助:
    邢台市重点研发计划项目(2023ZC072)

Research progress on the correlation and mechanism of gastric microbiota and occurrence and development of gastric cancer

Xiaobin Fan1, Yingshu Lyu1, Ruijuan Zhang1, Wenxing Li2, Yanjun Lian1,()   

  1. 1 Department of Gastrointestinal Surgery, Xingtai Central Hospital, Xingtai 054000, China
    2 Department of Gastrointestinal Surgery, Second Hospital of Shanxi Medical University, Taiyuan 030001, China
  • Received:2025-03-20 Published:2025-10-15
  • Corresponding author: Yanjun Lian
引用本文:

范晓彬, 吕英淑, 张瑞娟, 李文星, 连彦军. 胃微生物菌群与胃癌发生发展的相关性及其作用机制研究进展[J/OL]. 中华实验和临床感染病杂志(电子版), 2025, 19(05): 265-270.

Xiaobin Fan, Yingshu Lyu, Ruijuan Zhang, Wenxing Li, Yanjun Lian. Research progress on the correlation and mechanism of gastric microbiota and occurrence and development of gastric cancer[J/OL]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2025, 19(05): 265-270.

胃癌是全球常见的恶性肿瘤之一,其发病机制复杂,涉及遗传、环境和饮食等多种因素。近年来,胃微生物菌群与胃癌的相关性逐渐成为研究热点,越来越多的研究表明,胃微生物菌群在胃癌的发生、发展中起着重要作用。本综述系统阐述胃微生物菌群的组成、变化与胃癌发生发展的关系,包括幽门螺杆菌、非幽门螺杆菌细菌、真菌和病毒等微生物感染与胃癌的关联,以及微生物菌群失调对胃癌发生、发展的影响及其作用机制。同时,也对现有研究的局限性和未来研究方向进行探讨,为胃癌的预防和治疗提供新的思路和策略。

Gastric cancer is one of the most common malignant tumors worldwide, and its pathogenesis is complex, including genetic, environmental and dietary factors. In recent years, the relationship between gastric microbiota and gastric cancer has gradually become a hot research topic. More and more studies have shown that gastric microbiota plays an important role in the occurrence and development of gastric cancer. This review systematically expounds the relationship between the composition and changes of gastric microbiota and the occurrence and development of gastric cancer, including the association between microbial infections such as Helicobacter pylori, non-Helicobacter pylori bacteria, fungi and viruses and gastric cancer, as well as the influence and mechanism of microbial imbalance on gastric cancer. At the same time, the limitations of existing research and future research directions are also discussed, which provides new ideas and strategies for the prevention and treatment strategies of gastric cancer.

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