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中华实验和临床感染病杂志(电子版) ›› 2025, Vol. 19 ›› Issue (04) : 193 -196. doi: 10.3877/cma.j.issn.1674-1358.2025.04.001

综述

肝肿瘤内微生物对肝癌发生发展的影响
孙依阳1, 魏飞力1,2, 侯维1, 胡中杰1,()   
  1. 1100069 北京,首都医科大学附属北京佑安医院肝病中心
    2100069 北京,北京肝病研究所
  • 收稿日期:2025-04-15 出版日期:2025-08-15
  • 通信作者: 胡中杰
  • 基金资助:
    首都卫生发展科研专项(No.首发2022-2-2183); 北京市高层次公共卫生技术人才建设项目(No. 2022-2-005)

Influence of intratumoral microbiome on the occurrence and development of liver cancer

Yiyang Sun1, Feili Wei1,2, Wei Hou1, Zhongjie Hu1,()   

  1. 1Beijing Institute of Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China
    2Beijing Institute of Hepatology, Beijing 100069, China
  • Received:2025-04-15 Published:2025-08-15
  • Corresponding author: Zhongjie Hu
引用本文:

孙依阳, 魏飞力, 侯维, 胡中杰. 肝肿瘤内微生物对肝癌发生发展的影响[J/OL]. 中华实验和临床感染病杂志(电子版), 2025, 19(04): 193-196.

Yiyang Sun, Feili Wei, Wei Hou, Zhongjie Hu. Influence of intratumoral microbiome on the occurrence and development of liver cancer[J/OL]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2025, 19(04): 193-196.

国家癌症中心2024年全国癌症报告显示,肝癌仍是我国第二大癌症死亡原因。大量研究发现,结直肠癌、胰腺癌和乳腺癌等癌组织中广泛存在微生物,且构成与正常组织中的微生物存在一定差异。此外,也有研究发现,肿瘤组织内微生物对肿瘤的发生、发展具有重要的影响,免疫微环境、代谢途径、表观遗传修饰可能是主要的发生机制。本文对肝癌组织微生物影响肿瘤发生及发展的途径及在临床治疗和预防中的作用进行综述。

According to the National Cancer Center’s 2024 National Cancer Report, liver cancer remains the second leading cause of cancer death in our country. A large number of studies have found that microbes are widely present in various types of cancer tissues such as colorectal cancer, pancreatic cancer and breast cancer. Their composition is different from that of normal tissues. In addition, some studies have found that intratumoral microbiome has an important effect on the occurrence, development of tumors. The immune microenvironment, metabolic pathways and epigenetic modification might be the main mechanisms. In this paper, the ways that the intratumoral microbiome of liver cancer affected tumour occurrence and development, and the role in clinical treatment and prevention were reviewed.

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