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中华实验和临床感染病杂志(电子版)

中华实验和临床感染病杂志(电子版) ›› 2022, Vol. 16 ›› Issue (04) : 234 -238. doi: 10.3877/cma.j.issn.1674-1358.2022.04.003

综述

嗜酸性粒细胞在传染病诊断中的价值
钟炎平1, 赵琴2, 杨军杰3, 毛静1, 刘鑫华1, 李姗4, 刘园园5, 雷旭1, 雷飞飞1, 饶荣2, 谭华炳1,†()   
  1. 1. 442000　十堰市，湖北医药学院附属人民医院（十堰市人民医院）感染性疾病科　肝病研究所
    2. 442000　十堰市，湖北医药学院附属人民医院（十堰市人民医院）感染性疾病科　肝病研究所；442100　房县，房县人民医院检验科
    3. 442000　十堰市，湖北医药学院附属人民医院（十堰市人民医院）感染性疾病科　肝病研究所；442000　十堰市，锦州医科大学十堰市人民医院研究生培养基地
    4. 442000　十堰市，湖北医药学院附属人民医院（十堰市人民医院）感染性疾病科　肝病研究所；442000　十堰市，湖北医药学院附属国药东风总医院呼吸内科
    5. 442000　十堰市，湖北医药学院附属人民医院（十堰市人民医院）感染性疾病科　肝病研究所；441300　随州市，随州市中心医院（湖北医药学院附属随州医院）感染性疾病科
  • 收稿日期:2022-01-26 出版日期:2022-08-15
  • 通信作者: 谭华炳
  • 基金资助:
    国家自然科学基金青年科学基金资助项目(No. 82002149); 2021年十堰市科学技术研究与开发项目计划(No. 2021K65); 湖北医药学院"新冠肺炎"自然科学科研项目(No. 2020XGFYZR16); 2014年度湖北省教育厅科学研究计划(No. Q20142106); 2020年十堰市第一批市级新冠肺炎防控技术引导性应急科研项目(No. 20Y34、20Y41); 2022年度十堰市科技局引导性科研项目(No. 22Y69); 2022年湖北医药学院研究生科技创新项目(No. 2022HBUMY066)

Progress on eosinophilic granulocyte in diagnosis of infectious diseases

Yanping Zhong1, Qin Zhao2, Junjie Yang3, Jing Mao1, Xinhua Liu1, Shan Li4, Yuanyuan Liu5, Xu Lei1, Feifei Lei1, Rong Rao2, Huabing Tan1,†()   

  1. 1. Department of Infectious Diseases, Hepatology Institute, Renmin Hospital, Hubei University of Medicine, Shiyan 442000, China
    2. Department of Infectious Diseases, Hepatology Institute, Renmin Hospital, Hubei University of Medicine, Shiyan 442000, China; Department of Clinical Laboratory, Fang County Renmin Hospital, Fang County 442100, China
    3. Department of Infectious Diseases, Hepatology Institute, Renmin Hospital, Hubei University of Medicine, Shiyan 442000, China; Shiyan Renmin Hospital Postgraduate Training Base, Jinzhou Medical University, Shiyan, Hubei 442000, China
    4. Department of Infectious Diseases, Hepatology Institute, Renmin Hospital, Hubei University of Medicine, Shiyan 442000, China; Department of Respiratory Medicine, Sinopharm Dongfeng General Hospital, Hubei University of Medicine
    5. Department of Infectious Diseases, Hepatology Institute, Renmin Hospital, Hubei University of Medicine, Shiyan 442000, China; Department of Infectious Diseases, Suizhou Hospital, Hubei University of Medicine, Suizhou 441300, China
  • Received:2022-01-26 Published:2022-08-15
  • Corresponding author: Huabing Tan
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钟炎平, 赵琴, 杨军杰, 毛静, 刘鑫华, 李姗, 刘园园, 雷旭, 雷飞飞, 饶荣, 谭华炳. 嗜酸性粒细胞在传染病诊断中的价值[J]. 中华实验和临床感染病杂志(电子版), 2022, 16(04): 234-238.

Yanping Zhong, Qin Zhao, Junjie Yang, Jing Mao, Xinhua Liu, Shan Li, Yuanyuan Liu, Xu Lei, Feifei Lei, Rong Rao, Huabing Tan. Progress on eosinophilic granulocyte in diagnosis of infectious diseases[J]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2022, 16(04): 234-238.

对嗜酸性粒细胞（EOS）在传染病诊断中的价值进行综述，以提高传染病诊断中对EOS的认知。在万方数据、维普网、中国知网以"嗜酸性粒细胞"、"嗜酸性粒细胞+传染病或肺吸虫病、血吸虫病、恙虫病（TD）"、"嗜酸性粒细胞+结核病或伤寒"为检索词，检索时间为2010年1月至2021年12月。EOS是人体固有免疫细胞，参与指导B淋巴细胞和T淋巴细胞的功能，调节机体免疫反应，发挥抗炎作用，在传染病诊断和治疗过程中发挥作用。EOS在寄生虫（肺吸虫、血吸虫以及旋毛虫等）感染者显著升高，而在TD患者中水平下降，甚至降为"0"；在结核分枝杆菌和隐球菌感染时EOS升高，而在伤寒杆菌感染时降低，甚至降为"0"。EOS在寄生虫病、恙虫病、结核分枝杆菌、隐球菌感染和伤寒等传染病中呈现特征性变化，对指导上述疾病诊断具有重要价值。

关键词: 嗜酸性粒细胞, 固有免疫细胞, 寄生虫病, 恙虫病, 结核, 伤寒

The value of eosinophilic granulocyte (EOS) in the diagnosis of infectious diseases was reviewed to improve the understanding of the application value of EOS. Key words such as "eosinophilic granulocyte" , "eosinophilic granulocyte + infectious disease or paragonimiasis, or schistosomiasis, or trichinosis, or tsutsugamushi disease" , "eosinophilic granulocyte + tuberculosis, or typhoid fever" were searched in Wanfang, Weipu, CNKI databases. The retrieval period was from January 2010 to December 2021. EOS is an inherent immune cell of human body, which participates in guiding the function of B lymphocytes and T lymphocytes, regulating the immune response, playing a role in the anti-inflammatory response and treatment of infectious diseases. EOS increased significantly in patients with parasites infection (paragonimiasis, schistosomiasis and trichinella spiralis, etc). In patients with tsutsugamushi disease, EOS decreased or even decreased to "0" ; EOS increased in patients infected with Mycobacterium tuberculosis and Cryptococcus, which decreased or even decreased to "0" in patients infected with Typhoid bacillus. EOS presents characteristic changes in patients with parasitic diseases, scrub typhus, Mycobacterium tuberculosis, Cryptococcus, typhoid and other infectious diseases, which was valuable in guiding the diagnosis.

Key words: Eosinophilic granulocyte, Innate immune cell, Parasitic disease, Tsutsugamushi disease, Tuberculosis, Typhoid
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