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中华实验和临床感染病杂志(电子版) ›› 2016, Vol. 10 ›› Issue (05) : 522 -526. doi: 10.3877/cma.j.issn.1674-1358.2016.05.003

所属专题: 指南共识

指南

抗乙型肝炎病毒核苷(酸)类似物不良反应管理专家共识
抗乙型肝炎病毒核苷(酸)类似物不良反应管理专家委员会   
  • 收稿日期:2016-08-22 出版日期:2016-10-15
  • 基金资助:
    北京市医院管理局扬帆计划项目(肝炎专业)(No. ZYLX201402); 登峰计划项目(肝病专业)(No. DFL20151701); 北京市卫生系统高层次卫生技术人才培养计划(No. 2015-3-108); 北京市医院管理局临床医学发展专项经费资助(No. ZY201402)

Consensus on management of side effects of nucleos(t)ide analogues for hepatitis B virus

Experts Committee of management of side effects of nucleos(t)ide analogues for hepatitis B virus   

  • Received:2016-08-22 Published:2016-10-15
引用本文:

抗乙型肝炎病毒核苷(酸)类似物不良反应管理专家委员会. 抗乙型肝炎病毒核苷(酸)类似物不良反应管理专家共识[J]. 中华实验和临床感染病杂志(电子版), 2016, 10(05): 522-526.

Experts Committee of management of side effects of nucleos(t)ide analogues for hepatitis B virus. Consensus on management of side effects of nucleos(t)ide analogues for hepatitis B virus[J]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2016, 10(05): 522-526.

核苷(酸)类似物(NAs)是当前慢性乙型肝炎抗病毒治疗的主要药物,核苷(酸)类似物具有迅速抑制HBV复制和安全性良好的特点,但随着NAs的应用推广,NAs相关的肾脏、骨骼、肌肉及神经系统等不良反应的报道逐渐增加,这些不良反应的总体发生率并不高,但若不及时发现与处理有可能引起较为严重的临床后果。为优化NAs相关不良反应的临床管理,抗乙型肝炎病毒核苷(酸)类似物不良反应管理专家委员会结合最新的循证医学证据形成本共识。

Nucleos(t)ide analogues (NAs) are the main agents in anti-HBV therapy. NAs are potent in inhibiting HBV replication and have good safety profiles. With more and more patients taking NAs, case reports about the side effects on kidney, bone, muscle and neurological are also increasing. The incidences of these side effects are very low, but they may cause severe consequences. To optimize the management of NAs related side effects, we drafted the experts’ consensus on management of side effects of nucleos(t)ide analogues for hepatitis B virus.

表1 循证医学证据等级[1,2]
表2 5种常用NAs不良反应发生情况[3]
表3 TDF根据肌酐清除率调整给药间隔标准
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